Publikationen

Byun, S, Park, C, Suh, JY, Witte, CP, Rhee, S (2024): Structure, cooperativity and inhibition of the inosine 5′‐monophosphate‐specific phosphatase from Saccharomyces cerevisiae,  The FEBS Journal 291 (9), 1992-2008
DOI: 10.1111/febs.17093

Leite Dias, S., Chuang, L., Liu, S., Seligmann, B., Brendel, FL, Chavez, BG, Hoffie, RE, Hoffie, I, Kumlehn, K., Bültemeier, A., Wolf, J., Herde, M., Witte, C-P., D'auria, J, and Franke, J. (2024): Biosynthesis of the allelopathic alkaloid gramine in barley by a cryptic oxidative rearrangement,  Science 383 (6690), 1448-1454
DOI: 10.1126/science.adk6112

Rinne, J, Niehaus, M, Medina-Escobar, N, Straube, H, Schaarschmidt, F, Rugen, N, Braun, H-P, Herde, M, Witte, C-P (2024): Three Arabidopsis UMP kinases have different roles in pyrimidine nucleotide biosynthesis and (deoxy) CMP salvage,  The Plant Cell, koae170
DOI: 10.1093/plcell/koae170

Witte, C-P, Herde, M (2024): Nucleotides and nucleotide derivatives as signal molecules in plants,  Journal of Experimental Botany, erae377
DOI: 10.1093/jxb/erae377

Chen, X., Kim, S.-H., Rhee, S., Witte, C.-P. (2023): A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis,  The Plant Cell, Volume 35, Issue 1, 510–528, koac320
DOI: 10.1093/plcell/koac320

Freke, R., Heinemann, B., Hakim, S.E., Witte, C.-P., Herde, M., Hildebrandt, T.M., Franke J. (2023): Isotope‐guided metabolomics reveals divergent incorporation of valine into different flavor precursor classes in chives,  ChemBioChem e202300056, 24
DOI: 10.1002/cbic.202300056

Gao, S, Sun, Y, Chen, X, Zhu, C, Liu, X, Wang, W, Gan, L, Schaarschmidt, F, Herde, M, Witte, C-P and Chen M (2023): Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA,  Nucleic Acids Research, Volume 51, Issue 14, 7451–7464.
DOI: 10.1093/nar/gkad529

Straube, H., Straube, J., Rinne, J., Fischer, L., Niehaus, M., Witte, C.-P., Herde, M. (2023): An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides,  New Phytologist 237, 1759-1775
DOI: 10.1111/nph.18656

Valifard, M., Fernie, A.R., Kitashova, A., Nägele, T., Schröder, R., Meinert, M., Pommerrenig, B., Mehner-Breitfeld, D., Witte, C.-P., Brüser, T., Keller, I., Neuhaus, H.E. (2023): The novel chloroplast glucose transporter pGlcT2 affects adaptation to extended light periods,  Journal of Biological Chemistry, Volume 299, Issue 6, 104741
DOI: 10.1016/j.jbc.2023.104741

Wang, W, Liu, H, Wang, F, Liu, X, Sun, Y, Zhao, J, Zhu, C, Gan, L, Yu, J, Witte, C-P, Chen, M (2023): N4-acetylation of cytidine in (m)RNA plays essential roles in plants,  The Plant Cell, Volume 35, Issue 10, 3739–3756, koad189
DOI: 10.1093/plcell/koad189

Niehaus, M., Straube, H., Specht, A., Baccolini, C., Witte, C.-P., Herde, M. (2022): The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development,  The Plant Cell 34, 3790-3813.
DOI: 10.1093/plcell/koac207

Voß, L., Heinemann K.J., Herde, M., Medina-Escobar, N., Witte, C.-P. (2022): Enzymes and cellular interplay required for flux of fixed nitrogen to ureides in bean nodules.,  Nature Communications 13, 5331
DOI: 10.1038/s41467-022-33005-5

Heinemann, K. J., Yang, S.-Y., Straube H., Medina-Escobar N., Varbanova-Herde M., Herde M., Rhee S., Witte C.-P. (2021): Initiation of cytosolic plant purine nucleotide catabolism involves a monospecific xanthosine monophosphate phosphatase,  Nature Communications 12, 6846
DOI: 10.1038/s41467-021-27152-4

Kim, S.-H., Witte, C.-P, Rhee, S. (2021): Structural basis for the substrate specificity and catalytic features of pseudouridine kinase from Arabidopsis thaliana,  Nucleic Acids Research 49, 491–503.
DOI: 10.1093/nar/gkaa1144

Rinne, J., Witte, C.-P. and Herde, M. (2021): Loss of MAR1 Function is a Marker for Co-Selection of CRISPR-Induced Mutations in Plants,  Frontiers in Genome Editing, 09 August 2021
DOI: 10.3389/fgeed.2021.723384

Straube, H., Witte, C.P., Herde, M. (2021): Analysis of Nucleosides and Nucleotides in Plants: An Update on Sample Preparation and LC–MS Techniques,  Cells 10, 689.
DOI: 10.3390/cells10030689

Zhu et. al (u.a. Herde, M.) (2021): Calmodulin-like protein CML24 interacts with CAMTA2 and WRKY46 to regulate ALMT1-dependent Al resistance in Arabidopsis thaliana,  New Phytologist 233, 2471–2487
DOI: 10.1111/nph.17812

Chen, M., Witte, C.-P. (2020): A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation,  The Plant Cell 32, 722-739.
DOI: 10.1105/tpc.19.00639

Durian G, Sedaghatmehr M, Matallana-Ramirez L P, Schilling S, Schaepe S, Guerra T, Herde M, Witte C-P, Müller-Röber B, Schulze W X, Balazadeh S, Romeis T (2020): Calcium-Dependent Protein Kinase CPK1 Controls Cell Death by In Vivo Phosphorylation of Senescence Master Regulator ORE1,  The Plant Cell 32, 1610-1625.
DOI: 10.1105/tpc.19.00810

Niehaus, M., Straube, H., Künzler, P., Rugen, N., Hegermann, J., Giavalisco, P., Eubel, H., Witte, C.-P., Herde, M. (2020): Rapid affinity purification of tagged plant mitochondria (Mito-AP) for metabolome and proteome analyses,  Plant Physiology 182, 1194–1210.
DOI: 10.1104/pp.19.00736

Safavi-Rizi, V., Herde, M. and Stöhr, C. (2020): RNA-Seq reveals novel genes and pathways associated with hypoxia duration and tolerance in tomato root,  Scientific Reports 10, 1-17.

Straube, H., Niehaus, M., Zwittian, S., Witte, C.-P., Herde, M. (2020): Enhanced nucleotide analysis enables the quantification of deoxynucleotides in plants and algae revealing connections between nucleoside and deoxynucleoside metabolism,  The Plant Cell 33, 270–289.
DOI: 10.1093/plcell/koaa028

Witte, C.-P. and Herde, M. (2020): Nucleotide metabolism in plants,  Plant Physiology 182, 63–78.
DOI: 10.1104/pp.19.00955

Baccolini, C., Witte, C.P. (2019): AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, which Is Degraded by a Nucleoside Hydrolase Heterocomplex,  The Plant Cell 31, 734–751.
DOI: 10.1105/tpc.18.00899

Chen, M. and Witte, C.-P. (2019): Functions and Dynamics of Methylation in Eukaryotic mRNA,  In: Jurga S., Barciszewski J. (eds) The DNA, RNA, and Histone Methylomes. RNA Technologies. Springer, Cham, 333-351.
DOI: 10.1007/978-3-030-14792-1_13

Kang, P.-A., Oh, J., Lee, H., Witte, C.-P., Rhee, S. (2019): Crystal structure and mutational analyses of ribokinase from Arabidopsis thaliana,  Journal of Structural Biology 206, 110-118.
DOI: 10.1016/j.jsb.2019.02.007

Liu, B., Winkler, F., Herde, M., Witte, C.-P., Großhans, J. (2019): A link between deoxyribonucleotide metabolites and embryonic cell cycle control,  Current Biology 29, 1187-1192.
DOI: 10.1016/j.cub.2019.02.021

Chen, M., Urs, M.J., Sánchez-González, I., Olayioye, M.A., Herde, M., Witte C.-P. (2018): m6A RNA Degradation Products are Catabolized by an Evolutionarily Conserved N6-methyl-AMP Deaminase in Plant and Mammalian Cells,  The Plant Cell 30, 1511–1522.
DOI: 10.1105/tpc.18.00236

Kirchner, T.W., Niehaus, M., Rössig, K.L., Lauterbach, T., Herde, M., Küster, H. and Schenk , M.K. (2018): Molecular background of Pi deficiency-induced root hair growth in Brassica carinata – A fasciclin-like arabinogalactan protein is involved,  Frontiers in Plant Science 9, 1372.
DOI: 10.3389/fpls.2018.01372

Schroeder, R.Y., Zhu, A., Eubel, H., Dahncke, K., Witte, C.-P. (2018): The ribokinases of Arabidopsis thaliana and Saccharomyces cerevisiae are required for ribose recycling from nucleotide catabolism which in plants is not essential to survive prolonged dark stress,  New Phytologist 217, 233-244.
DOI: 10.1111/nph.14782

Kirchner, T.W., Niehaus, M., Debener, T., Schenk, M.K., Herde, M. (2017): Efficient generation of mutations mediated by CRISPR/Cas9 in the hairy root transformation system of Brassica carinata,  PLOS ONE 12, 0185429.
DOI: 10.1371/journal.pone.0185429

Myrach, T., Zhu, A., Witte, C.-P. (2017): The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease,  The Journal of Biological Chemistry 292, 14556-14565.
DOI: 10.1074/jbc.M117.780403

Yang, Z.-B., He, C., Ma, Y., Herde, M., Ding, Z. (2017): Jasmonic acid enhances Al-induced root-growth inhibition,  Plant Physiology 173, 1420–1433.
DOI: 10.1104/pp.16.01756

Yilamujiang, A., Zhu, A., Ligabue-Braun, R., Bartram, S., Witte, C.-P., Hedrich, R., Hasabe, M., Schöner, C.R., Schöner, M.G., Kerth, G., Carlini, C.R. & Mithöfer, A. (2017): Coprophagous features in carnivorous Nepenthes plants: a task for ureases,  Scientific Reports 7, 11647.
DOI: 10.1038/s41598-017-11999-z

Chen, M., Herde, M., Witte, C.P. (2016): Of the nine cytidine deaminase like genes in Arabidopsis thaliana eight are pseudogenes and only one is required to maintain pyrimidine homeostasis in vivo,  Plant Physiology 171, 799-809.
DOI: 10.1104/pp.15.02031

Fleck, A.T., Schulze, S., Hinrichs, M., Specht, A., Waßmann, F., Schreiber, L., Schenk, M.K. (2015): Silicon Promotes Exodermal Casparian Band Formation in Si-Accumulating and Si-Excluding Species by Forming Phenol Complexes,  PLoS ONE 10(9): e0138555.
DOI: 10.1371/journal.pone.0138555

Klug, K., Hogekamp, C., Specht, A., Shwe Myint, S., Blöink, D., Küster, H., Horst, W.J. (2015): Spatial gene expression analysis in tomato hypocotyls suggests cysteine as key precursor of vascular sulfur accumulation implicated in Verticillium dahliae defense,  Physiologia Plantarum 153, 253–268

Matschi, S., Hake, K., Herde, M., Hause, B. and Romeis, T. (2015): The Calcium-Dependent Protein Kinase CPK28 Regulates Development by Inducing Growth Phase-Specific, Spatially Restricted Alterations in Jasmonic Acid Levels Independent of Defense Responses in Arabidopsis,  The Plant Cell 27, 591-606.
DOI: 10.1105/tpc.15.00024​​

Hauck, O.K., Scharnberg, J., Medina Escobar, N., Wanner, G., Giavalisco, P., Witte, C.P. (2014): Uric acid accumulation in an Arabidopsis urate oxidase mutant impairs seedling establishment by blocking peroxisome maintenance,  The Plant Cell 26, 3090-3100.
DOI: 10.1105/tpc.114.124008

Herde, M., Howe G.A. (2014): Host plant-specific remodeling of midgut physiology in the generalist insect herbivore Trichoplusia ni,  Insect Biochemistry and Molecular Biology 50, 58-67.
DOI: 10.1016/j.ibmb.2014.03.013

Romeis, T., Herde, M. (2014): From local to global: CDPKs in systemic defense signaling upon microbial and herbivore attack,  Current Opinion in Plant Biology 20, 1-10.
DOI: 10.1016/j.pbi.2014.03.002

Bollig, K., Specht, A., Myint, S. S., Zahn, M., Horst, W. J. (2013): Sulphur supply impairs spread of Verticillium dahliae in tomato,  European Journal of Plant Pathology 135, 81-96

Chuang, W.-P., Herde, M., Ray, S., Castano-Duque, L., Howe, G.A., Luthe, D.S. (2013): Caterpillar attack triggers accumulation of the toxic maize protein RIP2,  New Phytologist 201, 928-939.
DOI: 10.1111/nph.12581

Dahncke, K., Witte, C.P. (2013): Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis,  The Plant Cell 25, 4101-4109.
DOI: 10.1105/tpc.113.117184

Dubiella, U., Seybold, H., Durian, G., Komander, E., Lassig, R., Witte, C.P., Schulze, W.X., Romeis, T. (2013): Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation,  Proceedings of the National Academy of Sciences of the United States of America 110, 8744-8749.
DOI: 10.1073/pnas.1221294110

Herde, M., Koo, A.J.K., Howe, G.A. (2013): Elicitation of jasmonate-mediated defense responses by mechanical wounding and insect herbivory,  Methods in Molecular Biology 1011, 51-61.
DOI: 10.1007/978-1-62703-414-2_5

Nakata, M., Mitsuda, N.,Herde, M., Koo, A.J.K., Moreno, J.E., Suzuki, K., Howe, G.A., Ohme-Takagi, M. (2013): A bHLH-type transcription factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, acts as a repressor to negatively regulate jasmonate signaling in Arabidopsis,  The Plant Cell 25, 1641-1656.
DOI: 10.1105/tpc.113.111112

Schulz, P., Herde, M., Romeis, T. (2013): Calcium-Dependent Protein Kinases: Hubs in plant stress signaling and development,  Plant Physiology 163, 523-530.
DOI: 10.1104/pp.113.222539

Werner, A.K., Medina-Escobar, N., Zulawski, M., Sparkes, I.A., Cao, F.Q., Witte, C.P. (2013): The ureide degrading reactions of purine ring catabolism employ one aminohydrolase and three amidohydrolases in Arabidopsis, soybean and rice,  Plant Physiology 163, 672-681.
DOI: 10.1104/pp.113.224261

Claus-Peter Witte (2012): Die Remobilisierung von Stickstoff aus Nukleotiden und Harnstoff in Pflanzen. ,  Habilitation in Botanik am Fachbereich für Biologie, Chemie und Pharmazie der Freien Universität Berlin

Führs, H., Specht, A., Erban, A., Kopka, J., Horst, W.J. (2012): Functional associations between the metabolome and manganese tolerance in Vigna unguiculata,  Journal of Experimental Botany Vol. 63, No. 1, pp 329-340

Klug, B., Specht, A., Horst, W.J. (2011): Aluminium localisation in root tips of the aluminium-accumulating plant species buckwheat (Fagopyrum esculentum Moench),  Journal of Experimental Botany Vol. 62, No. 15, pp. 5453-5462

WANG, Y., SPECHT, A., HORST, W.J. (2011): Stable isotope labelling and zinc distribution in grains studied by laser ablation ICP-MS in an ear culture system reveals zinc transport barriers during grain filling in wheat.,  New Phytologist 189, 428-437.

Werner, A.K., Witte, C.P. (2011): The biochemistry of nitrogen mobilization: purine ring catabolism,  Trends in Plant Science 16, 381-387.
DOI: 10.1016/j.tplants.2011.03.012

Witte, C.P. (2011): Urea metabolism in plants,  Plant Science 180, 431-438.
DOI: 10.1016/j.plantsci.2010.11.010

Cao, F.Q., Werner, A.K., Dahncke, K., Romeis, T., Liu, L.H., Witte, C.P. (2010): Identification and characterization of proteins involved in rice urea and arginine catabolism,  Plant Physiology 154, 98-108.
DOI: 10.1104/pp.110.160929

Lee, S., Badieyan, S., Bevan, D., Herde, M., Gatz, C., Tholl, D. (2010): Herbivore-induced and floral homoterpene volatiles are biosynthesized by a single CytP450 enzyme (CYP82G1) in Arabidopsis ,  Proceedings of the National Academy of Sciences of the United States of America 107, 21205-21210.
DOI: 10.1073/pnas.1009975107

Werner, A.K., Romeis, T., Witte, C.P. (2010): Ureide catabolism in Arabidopsis thaliana and Escherichia coli ,  Nature Chemical Biology 6, 19-21.
DOI: 10.1038/nchembio.265

Witte, C.P, Dubiella, U., Seal, A., Zappel, N., Demoulière, R., Romeis, T. (2010): Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response,  Journal of Biological Chemistry 285, 9740-9748.
DOI: 10.1074/jbc.M109.052126

FÜHRS, H., GÖTZE, S., SPECHT, A., ERBAN, A., GALLIEN, S., HEINTZ, D., VAN DORSSELAER, A., KOPKA, J., BRAUN, H.-P., HORST, W.J. (2009): Characterization of leaf apoplastic peroxidases and metabolites in Vigna unguiculata in response to toxic manganese supply and silicon.,  J. Exp. Bot. 60, 1663-1678.

Herde, M., Gärtner, K., Köllner, T.G., Fode, B., Boland, W., Gershenzon, J., Gatz, C., Tholl, D. (2008): Identification and regulation of TPS04/GES, an Arabidopsis geranyllinalool synthase catalyzing the first step in the formation of the insect-induced volatile C16-homoterpene TMTT,  The Plant Cell 20, 1152-1168.
DOI: 10.1105/tpc.106.049478

Werner, A.K., Sparkes, I.A., Romeis, T., Witte, C.P. (2008): Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean,  Plant Physiology 146, 418-430.
DOI: 10.1104/pp.107.110809

Noël, L.D., Cagna, G., Stuttmann, J., Wirthmüller, L., Betsuyaku, S., Witte, C.P., Colby, T. and Parker, J.E. (2007): Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses,  Plant Cell 19, 4061-4076.

Böhmer, M., Kurth, J., Witte, C.P., Romeis, T. (2005): Function of plant Calcium-Dependent Protein Kinases in the activation of abiotic and pathogen-related stress responses and its potential application in the generation of stress-resistant plants,  Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues (1st Edition), J.A. Teixeira da Silva, ed (New Dehli):Regency Publications.

Witte, C.P., Rosso, M.G., Romeis, T. (2005): Identification of three urease accessory proteins that are required for urease activation in Arabidopsis thaliana,  Plant Physiology 139, 1155-1162.

Witte, C.P., Tiller, S., Isidore, E., Davies, H.V., Taylor, M.A. (2005): Analysis of two alleles of the urease gene from potato: polymorphisms, expression and extensive alternative splicing of the corresponding mRNA ,  Journal of Experimental Botany 56, 91-99.

Iannetta, P.P., Medina Escobar, N., Ross, H.A., Souleyre, E.J.F., Hancock, R.D., Witte, C.P., Davies, H.V. (2004): Identification, cloning and expression analysis of strawberry (Fragaria ananassa) mitochondrial citrate synthase and mitochondrial malate dehydrogenase,  Physiologia Plantarum 121, 15-26.

Witte, C.P., Noel, L.D., Gielbert, J., Parker, J.E., Romeis, T. (2004): Rapid one-step protein purification from plant material using the eight-amino acid StrepII epitope,  Plant Molecular Biology 55, 135-147.

Ataya, F.S., Witte, C.P., Galvan, A., Igeno, M.I., Fernandez, E. (2003): Mcp1 encodes the molybdenum cofactor carrier protein in Chlamydomonas reinhardtii and participates in protection, binding, and storage functions of the cofactor,  Journal of Biological Chemistry 278, 10885-10890.

Glinski, M., Romeis, T., Witte, C.P., Wienkoop, S., Weckwerth, W. (2003): Stable isotope labeling of phosphopeptides for multiparallel kinase target analysis and identification of phosphorylation sites,  Rapid Communications in Mass Spectrometry 17, 1579-1584.

Bacanamwo, M., Freyermuth, S.K., Palacios, J.M., Witte, C.P., Polacco, J.C. (2002): Nitrification, denitrification and the N cycle,  Finan, T.M., O´Brian, M.R., Layzell, D.B., Vessey, J.K., Newton, W., eds., Nitrogen Fixation: Global Perspectives. CABI Publishing, Hamilton, Ontario, UK, pp 314-318.

Bacanamwo, M., Witte, C.P., Lubbers, M.W., Polacco, J.C. (2002): Activation of the urease of Schizosaccharomyces pombe by the UreF accessory protein from soybean,  Molecular Genetics and Genomics 268, 525-534.

Witte, C.P., Tiller, S.A., Taylor, M.A., Davies, H.V. (2002): Leaf urea metabolism in potato. Urease activity profile and patterns of recovery and distribution of N-15 after foliar urea application in wild-type and urease-antisense transgenics ,  Plant Physiology 128, 1129-1136.

Witte, C.-P., Isidore, E., Tiller, S.A., Davies, H.V., Taylor, M.A. (2001): Functional characterisation of urease accessory protein G (ureG) from potato ,  Plant Molecular Biology 45, 169-179.

Witte, C.-P., Medina-Escobar, N. (2001): In-gel detection of urease with nitroblue tetrazolium and quantification of the enzyme from different crop plants using the indophenol reaction ,  Analytical Biochemistry 290, 102-107.

Witte, C.-P., Tiller, S.A., Taylor, M.A., Davies, H.V. (2001): Addition of nickel to Murashige & Skoog medium in plant tissue culture activates urease and may reduce metabolic stress,  Plant Cell, Tissue and Organ Culture 68, 103-104.

Witte, C.P. (2001): Modifying Nitrogen Use Efficiency: Molecular Manipulation of Urea Metabolism in Leaves of Solanum tuberosum,  Promotion an der Universität Dundee in der Abteilung für Biochemie des Scottish Crop Research Institute, Dundee, Großbritannien.

Witte, C.P., Hien Le, Q., Bureau, T., Kumar, A. (2001): Terminal-repeat retrotransposons in miniature (TRIM) are involved in restructuring plant genomes,  Proceedings of the National Academy of Sciences of the United States of America, 13778-13783.

Witte, C.-P., Blasco, R., Castillo, F. (1998): Microbial photodegradation of aminoarenes. Metabolism of 2-amino-4-nitrophenol by Rhodobacter capsulatus ,  Applied Biochemistry and Biotechnology 69, 192-202.

Witte, C.-P., Igeño, M.I., Mendel, R., Schwarz, G., Fernández, E. (1998): The Chalmydomonas reinhardtii MoCo Carrier Protein is multimeric and stablilizes molybdopterin cofactor in a molybdate charged form ,  FEBS Letters 431, 205-209.